| ncRNA name | NgR siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas |
| Methods | siRNA injection, H&E staining, TUNEL assay, Western blot, immunohistochemistry, qPCR |
| Expression pattern | associated |
| Functional description | We found that NgR siRNA or CNTF injection alone significantly increased cell count in GCL in diabetic rats, inhibited ganglion cell apoptosis, elevated Bcl-2, F-actin and GAP-43, and decreased Bax, Caspase-3, NgR, RhoA and Rock1 levels. Combination treatment further prevented retinal ganglion cell loss, enhanced growth cone cytoskeleton and axonal regeneration, and suppressed NgR/RhoA/Rock1. |
| PubMed ID | 28656312 |
| Year | 2017 |
| Title | Nogo receptor knockdown and ciliary neurotrophic factor attenuate diabetic retinopathy in streptozotocin-induced diabetic rats. |
| Drug-related ncRNA | NO |
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